A study on productivity and profitability of cabbage applied with inorganic, bio-fertilizers, chicken manure and micronutrients was conducted at the Research Experiment Station of the University of Science and Technology of Southern Philippines (USTP), Claveria, Misamis Oriental from August to December 2018. The study was limited to gather the data on growth, physiology and yield as well as the cost and return analysis in one cropping season only. It was laid out in Split-plot in Randomized Complete Block Design (RCBD) with three main plots namely: (A1) Nutrio, (A2) Mykoplus and (A3) No bio-fertilizer. Different application of nutrients served as sub plots namely: (B1) control, (B2) RRIF, (B3) RRIF + chicken manure, (B4) ½ RRIF, (B5) RRIF + chicken manure + BZnCuMo and (B6) ½ RRIF + chicken manure + BZnCuMo. Key parameters gathered include: (A) growth parameters: plant stand and number of days to heading, (B) physiological parameters: dry matter yield and relative chlorophyll content, (C) yield and its components: number of leaves per head, head size (polar and equatorial), head weight (marketable and non-marketable), and (D) profitability computed using cost and return analysis. Results revealed that Nutrio can enhance the function of inorganic, chicken manure and micronutrients since it has highly significant value in terms of physiological and yield parameters compared to Mykoplus. The application of RRIF (150-100-160) + chicken manure (5 tons ha-1) have the highest number of leaves per head, head size (equatorial) and head weight which is highly relevant in attaining the maximum yield of 55.93 tons ha-1 of cabbage and therefore, attained the highest return on investment of 164.46%.